ADAMTS13: Biology and Disease - download pdf or read online

By George M. Rodgers

ISBN-10: 3319087169

ISBN-13: 9783319087160

ISBN-10: 3319087177

ISBN-13: 9783319087177

This accomplished quantity discusses the protease ADAMTS13, summarizing the present prestige of uncomplicated and medical examine. The 9 authoritative chapters start with a historic standpoint via exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its general functionality in hemostasis (cleavage of von Willebrand factor). rising study subject matters for ADAMTS13 are coated, together with its strength position in angiogenesis and different elements of telephone biology. extra themes contain laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and bought ADAMTS13 deficiency. A bankruptcy on comparable thrombotic microangiopathic (TMA) issues examines the variations among TMAs linked to ADAMTS13 deficiency and people now not linked to ADAMTS13 deficiency. a last bankruptcy reports the initial info on rising features of ADAMTS13, comparable to the prestige of recombinant ADAMTS13 items and their strength utility.

Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and sickness is an important source for medical hematologists, transfusion medication physicians, and researchers drawn to hemostasis, vascular biology, biochemistry, and metalloproteases.

Show description

Read or Download ADAMTS13: Biology and Disease PDF

Best hematology books

Download e-book for iPad: Hematopoietic Stem Cell Transplantation in Clinical Practice by Jennifer G. Treleaven MD FRCP FRCPath, A. John Barrett MD

A consultant to the perform of stem mobile transplantation, its prestige within the remedy of varied problems and the issues that come up after transplantation, geared toward the entire transplant staff. an up-to-the-minute advisor to top perform within the use of stem mobile transplantation, overlaying present prestige within the remedy of malignant and non-malignant stipulations, sensible elements and difficulties reminiscent of an infection and graft as opposed to host ailment.

New PDF release: Inhibitors in Patients with Haemophilia

Edited through an orthopaedic medical professional and a haematologist who're top experts within the therapy of haemophilia, Inhibitors in sufferers with Haemophilia stories the several haemostatic items and protocols for the regulate of bleeding and surgical procedure in haemophilic sufferers with inhibitors. The ebook attracts jointly in one quantity all the scientific matters occupied with the remedy of inhibitors from a variety of experts around the globe.

Atlas of Comparative Diagnostic and Experimental Hematology by Clifford Smith PDF

An essential source on blood and bone marrow telephone morphology in laboratory animal medication. This absolutely revised new version is a vital reference for medical pathologists in diagnostic laboratories, and scientific or veterinary study. The atlas comprises over four hundred colour photos of cells from the peripheral blood and bone marrow from numerous animals encountered in laboratory animal medication, in wellbeing and fitness and illness.

Download e-book for kindle: Blood Cells: A Practical Guide by Barbara J. Bain

Allows either the haematologist and laboratory scientist to spot blood mobile beneficial properties, from the most typical to the extra vague presents crucial details on equipment of assortment, blood movie practise and marking, including the rules of guide and automatic blood counts thoroughly revised and up to date, incorporating a lot newly released details: now comprises suggestion on extra assessments whilst a selected prognosis is suspected four hundred prime quality images to assist with blood mobile identity Highlights the aim and medical relevance of haematology laboratory checks all through

Extra resources for ADAMTS13: Biology and Disease

Sample text

A genetic defect of connective tissues. J Hered. 1974;65(6):356–8. 71. Lapiere CM, Lenaers A, Kohn LD. Procollagen peptidase: an enzyme excising the coordination peptides of procollagen. Proc Natl Acad Sci U S A. 1971;68(12):3054–8. 72. Nusgens BV, Verellen-Dumoulin C, Hermanns-Le T, De Paepe A, Nuytinck L, Pierard GE, Lapiere CM. Evidence for a relationship between Ehlers-Danlos type VII C in humans and bovine dermatosparaxis. Nat Genet. 1992;1(3):214–7. S. Apte 73. Colige A, Sieron AL, Li SW, Schwarze U, Petty E, Wertelecki W, Wilcox W, Krakow D, Cohn DH, Reardon W, Byers PH, Lapiere CM, Prockop DJ, Nusgens BV.

They lack the regions comprising the protease domain of ADAMTS proteases (Fig. 1), and, therefore, are not proteases [7]. S. Phil. M. S. Apte Protease domain Ancillary domain ADAMTS4 _ Signal peptide ADAMTS5/8 1 Propeptide ADAMTS1/15 2 Catalytic module ADAMTS9/20 14 TSR (central) ADAMTS6/10 4 Cysteine-rich module ADAMTS17/19 4 ADAMTS2/3/14 3 ADAMTS7/12 3 ADAMTS16/18 5 ADAMTS13 6 Disintegrin-like module Spacer n TSR (C-terminal) PLAC Shared modules Procollagen N-propeptidase CUB Mucin/proteoglycan Proteoglycanases Gon-1 related Procollagen aminopropeptidases 4 Mucin-proteoglycans vWF-protease Gon-1 Clade-specific modules Fig.

1211290109. Jacobi CL, Rudigier LJ, Scholz H, Kirschner KM. Transcriptional regulation by the Wilms tumor protein, Wt1, suggests a role of the metalloproteinase Adamts16 in murine genitourinary development. J Biol Chem. 2013;288(26):18811–24. 464644. Aldahmesh MA, Alshammari MJ, Khan AO, Mohamed JY, Alhabib FA, Alkuraya FS. The syndrome of microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) is caused by mutations in ADAMTS18. Hum Mutat. 2013;34(9):1195–9. 22374. Peluso I, Conte I, Testa F, Dharmalingam G, Pizzo M, Collin RW, Meola N, Barbato S, Mutarelli M, Ziviello C, Barbarulo AM, Nigro V, Melone MA, European Retinal Disease C, Simonelli F, Banfi S.

Download PDF sample

ADAMTS13: Biology and Disease by George M. Rodgers


by Ronald
4.2

Rated 4.28 of 5 – based on 19 votes