By Dr. Androulla Efeftheriou
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Extra info for About Thalassaemia
Iv) Liver toxicity -- increased levels of liver function tests (ALT) reported in a multicentre study, where generally transient and occurred more commonly in patients with Hepatitis C. Fluctuating liver function tests have required a small proportion of patients to stop using L1. One paper suggests that liver fibrosis may progress more rapidly in patients using L1 than those using DFO, although observations of a number of different studies (not designed for this purpose) and a recent evaluation by 3 independent pathologists of serial liver have so far failed to report progression of fibrosis.
Over recent years, a number of other tests have been developed that can reliably measure the amount of iron in the body. These tests are often carried out in conjunction with serum ferritin measurements in order to provide a more accurate picture of body iron loading, particularly in the liver and heart. Liver Iron Concentration (LIC) Measuring the concentration of iron in the liver involves removing cells from the liver tissue - a procedure known as a liver biopsy - and measuring the amount of iron they contain.
The complex that is created between the Iron molecule and that of Deferasirox is removed almost exclusively via the faeces. The drug, which is slowly metabolised in the liver, remains in the blood plasma for many hours (half-life between 9-11 hours). Therefore, one daily dose can be effective over a 24hour period. Effectiveness: According to published data, a dose of 20mg/kg stabilises the serum ferritin levels at about 2,000Ìg/l, while the higher dose of 30mg/kg can reduce the ferritin level by up to 1,000Ìg/l over one year of continuous administration.
About Thalassaemia by Dr. Androulla Efeftheriou