By Drew Provan
This ABC has demonstrated itself as a well-liked advent to scientific Haematology, suitable either for postgraduate scholars and first care practitioners. Now in its 3rd version, the ABC of medical Haematology has been completely revised, that includes the newest remedies for leukemia, antithrombotics and medicine for lymphoma and overlaying the most recent advances in hematology and bone marrow transplantation.
With every one bankruptcy written through experts of their respective fields, this can be an excellent easy textual content for normal perform and health center employees with sufferers who've blood similar difficulties, specifically GPs, hematology nurses, junior medical professionals, hematologists, and trainees in hematology.
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Additional resources for ABC of clinical haematology
Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. New England Journal of Medicine 2006; 12: 166–78. Tauro S, Craddock C, Peggs K et al. Allogeneic stem cell transplantation using a reduced intensity conditioning (RIC) regimen has the capacity to produce durable remissions and long term disease free survival in patients with high risk acute myeloid leukemia (AML) and myelodysplasia (MDS). Journal of Clinical Oncology 2005; 23: 9387–93. Acknowledgements The authors acknowledge the generosity of Matt Lawes and Mike Griffiths in the provision of photomicrographs.
Once CR has been achieved, the majority of patients receive a further two cycles of chemotherapy. In APL, treatment with myelosuppressive drugs, particularly anthracyclines, is combined with all-trans-retinoic acid, which is very active in this disease and has substantially improved outcome. Role of stem cell transplantation Allogeneic stem cell transplantation using an HLA identical sibling has the capacity to reduce the relapse rate and improve disease-free survival in patients with AML. Allogeneic transplantation is not indicated in patients with good risk cytogenetics, whose outcome with chemotherapy alone is encouraging, but is an important treatment modality in patients under the age of 45 years with standard or poor risk cytogenetics in first CR.
The molecular biology of chronic myeloid leukemia. Blood 2000; 96 :3343–56. Druker BJ, Guilhot P, O’Brien SG et al. Five-year follow-up of imatinib therapy for newly diagnosed chronic-phase chronic myeloid leukemia. New Eng J Med 2006; 355: 2408–17. Goldman JM, Druker B. Chronic myeloid leukemia: current treatment options. Blood 2001; 98: 2039–42. Goldman JM, Melo JV. Chronic myeloid leukemia. New England Journal of Medicine 2003; 349: 1449–62. Hughes T, Deininger M, Hochhaus A et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors – recommendations for ‘harmonizing’ current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results.
ABC of clinical haematology by Drew Provan